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The benefit of the treatment should be assessed after three months and trimetazidine should be discontinued if there is no treatment response.

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Elderly patients: Elderly patients may have increased trimetazidine exposure due to age-related decrease in renal function. In patients with moderate renal impairment (creatinine clearance [30-60] ml/min), the recommended dose is 1 tablet of 35mg in the morning during breakfast.

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